Methylation - MTR & MTRR

MTR = Methionine synthase
The role of MTR is to convert homocysteine back into methionine. To do this is uses a methyl group from 5-MTHF. Methyl B12 is a cofactor, and the process is dependent on Zinc.

MTRR - Methionine synthase reductase
The role of MTRR is to regenerate oxidized B12, and support MTR activity.  Vitamin B2 is a cofactor

If we have SNP's in one or both of these genes, this can leading to an associated degree of compromise in the methylation process.   However, we never assess methylation based on 1 or 2 genes.  We need to look at the entire picture before deciding if supplementation is necessary.  

Often the most sustainable way to address moderate levels of compromise, is to understand how to find the necessary nutrients in the diet.   This is a simple process that should be included in your genetic report.  After all, the only reason to get a genetic report is to understand what you can do to address any potential issues.

Supplementation if needed, should be tailored to directly intervene in your most problematic areas.  

Another aspect to consider is that not only are there factors that can increase gene activity, there are also factors that decrease gene activity.  For MTR these include:  excess alcohol, excess sugar and heavy metals.  MTRR can be negatively influenced by a number of common pharmaceutical drugs.